Just saw this one tonight. it was pretty decent. It definitely had some "gross out" humour, but it was mostly good. Sandler and Barrymore work really well together.
I agree, I went into this movie not expecting much because it appeared to be just another Sandler flick. I came away pleasantly surprised. There is actually some depth here and it really made you wonder how people with this type of memory loss function, etc. Barrymore and Sandler's chemistry was great as always and aside from some of the silly gross-out humor, I thought it was one of the best both have done recently.