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Guest
drug - drug, food - drug interactions
There are more (FDA) drug - drug interaction information. Drug - food interactions or herb - drug interactions information are less robust.
Grape fruit juice is an injhibitor of cytochrome P450 3A4 enzymes, and according to the available data, it inhibits the metabolism of clarithromycin (Biaxin) which is a substrate of 3A4. The clarithromycin - grape fruit juice interaction may increase the levels of clarithromycin in your blood, and may increase the risk of side effects of clarithromycin, but it seems like you are doing Ok.
I think hospitals quit serving grape fruit juice.
From pubmed abstract
www.ncbi.nlm.nih.gov/entr...t=Abstract
<blockquote><strong><em>Quote:</em></strong><hr>I know that if a woman is taking birth control pills that an antibiotic can render the bc pills useless.[/quote]
Well I do not think all antibiotics does that. BC pills like any drug has to be digested by liver enzymes, the only way another drug can render the BC useless is for it to induce a lot of liver enzymes. With an increase amount of liver enzymes the BC is digested away quicky.
Referring to the cytochrome P450 cyzyme table
medicine.iupui.edu/flockhart/
scroll down all the way to look at the inducers, rifampin and isonazid are the 2 antibiotics that function as inducers. Interestingly broccoli, brussel sprout, and tobacco are inducers of 1A2, and st. johns wort is an inducer of 3A4.
I have my bias for drugs that are FDA approved, because there are more information available on these drugs. Herbs OTOH are pharmacologically active, but there are less information available. (St. Johns's wort is the exception, there are tons of information about SJW)
There are more (FDA) drug - drug interaction information. Drug - food interactions or herb - drug interactions information are less robust.
Grape fruit juice is an injhibitor of cytochrome P450 3A4 enzymes, and according to the available data, it inhibits the metabolism of clarithromycin (Biaxin) which is a substrate of 3A4. The clarithromycin - grape fruit juice interaction may increase the levels of clarithromycin in your blood, and may increase the risk of side effects of clarithromycin, but it seems like you are doing Ok.
I think hospitals quit serving grape fruit juice.
From pubmed abstract
www.ncbi.nlm.nih.gov/entr...t=Abstract
<blockquote><strong><em>Quote:</em></strong><hr>I know that if a woman is taking birth control pills that an antibiotic can render the bc pills useless.[/quote]
Well I do not think all antibiotics does that. BC pills like any drug has to be digested by liver enzymes, the only way another drug can render the BC useless is for it to induce a lot of liver enzymes. With an increase amount of liver enzymes the BC is digested away quicky.
Referring to the cytochrome P450 cyzyme table
medicine.iupui.edu/flockhart/
scroll down all the way to look at the inducers, rifampin and isonazid are the 2 antibiotics that function as inducers. Interestingly broccoli, brussel sprout, and tobacco are inducers of 1A2, and st. johns wort is an inducer of 3A4.
I have my bias for drugs that are FDA approved, because there are more information available on these drugs. Herbs OTOH are pharmacologically active, but there are less information available. (St. Johns's wort is the exception, there are tons of information about SJW)