Unlikely if Rika cannot even do an optimal double 3A layout. I've said it before - "I don't think you even realize how strong Sasha's layout is". Rika Kihira does 3 non-axel doubles, Trusova 0.
Looking at Russia Cup, Trusova had one clean quad, one quad fall, and one quad pop and her TES was 90.47 while Rika's with a clean skate in her last GP event was 87.17. Trusova's BV was nearly 10 points higher. Yes, indeed, local scoring and inflated GOEs but still.
I am indeed making assumptions on Kihira's ability to land these quads while assuming Sasha doesn't pick up a 3A; looks like she's also on the way off-ice, although thats and probably less progress than Kihira's successful quads on ice.
If Kihira gets 4T, then given that she has been seen landing 3Lo combinations, she could start by removing her solo 3Lo, replacing it with 4T, move her 3Lo to replace the 2T in her 3Lz-2T. Then, if she gets 4S, she can replace her 3S and do 3Lz-Eu-3S, sort of like what Trusova is doing. It's a bunch of assumptions, I know, but I'm sure her coaches are aware of her competition and at least will consider tweakes like what I've proposed. I believe this proposal would leave her as the sole female skater with no doubles, unless Trusova and co get 3A.
I know this may be unrealistic, but it's a fun mental exercise

). And 4Lz/4T is stronger than 4S/4T. Having all three quads in one program is probably too much still for her. But I know, Sasha is just some poor weakling, having just two quads in her long program, with such feeble content she probably end last in JGP final and let her forget about any other titles for the rest of her life 
I have no doubt she can still do it, but is she actually considering doing it in competition again?
hwell: